What is CIMED?
CIMED™ (Complement Inhibition Monitoring and Efficacy Determination) is a proprietary platform engineered to measure complement activity under physiologic, high-serum conditions. Through pathway-resolved functional assays, it delivers mechanistic insights directly relevant to therapeutic monitoring and drug development.
Unlike conventional complement assays, CIMED kits are engineered to deliver clean, pathway-isolated data that is directly relevant to drug development and pharmacodynamic monitoring in clinical trials.
Why CIMED?
Built from the ground up for complement-targeted drug development.
Pathway-Specific
Each kit isolates a single complement pathway, eliminating crosstalk for clean, interpretable data.
Functional ELISA Format
Measures actual pathway activity, not just protein levels. Provides physiologically relevant results.
Drug Monitoring Ready
Purpose-built for pharmacodynamic assessment of complement-targeted therapeutics in clinical trials.
Research Use Only
Currently designated RUO. Developed under rigorous quality standards for translational and clinical research.
CIMED Product Suite
Three pathway-specific platforms covering the functional complement system.
CIMED-APTM
Alternative Pathway Activity & Drug Monitoring
Measures physiologic alternative pathway activity, amplification loop competence, and therapeutic drug effects under high-serum conditions.
- PNH, aHUS, gMG, NMOSD, C3G, IC-MPGN
- Complement drug development & mechanistic profiling
- Alternative pathway inhibitor monitoring
- Evaluation of off-target complement effects
CIMED-CPTM
Classical Pathway Immune Complex Activity
Measures immune-complex–driven classical pathway activation under physiologic serum conditions for mechanistic autoimmune profiling.
- CAD, SLE, vasculitis, immune-complex diseases
- Complement drug development & profiling
- Classical pathway inhibitor monitoring
- Biologic & immunotherapy safety assessment
CIMED-LPTM
Lectin Pathway Innate Immune Activation
Quantifies lectin-mediated complement activation for innate immune phenotyping and infection-related risk assessment.
- HSCT-TMA & innate immune profiling
- Infection susceptibility studies
- Translational research applications
- Lectin pathway inhibitor monitoring & safety surveillance
Applications
CIMED kits are designed to support a range of use cases across the complement therapeutics pipeline.
Pharmacodynamic (PD) drug monitoring in clinical trials
Complement pathway-specific inhibition profiling
Preclinical and translational research studies
Biomarker program development and validation
Clinical study sample analysis (serum/plasma)
Drug potency and mechanism-of-action studies